AIDS vaccine Research is a new breakthrough: strong antibody is successfully separated
Release time: 2010-08-02 & nbsp & nbsp & nbsp Source:
The latest issue of US authoritative magazine "Science" published two reports，At a time attracted countless attention。AIDS vaccine research that has been headache for scientists for a long time seems to have made breakthrough progress。American scientists are separated from HIV infected with a powerful antibody that can fight about 90%of the known HIV strains.。
The Voice of China Reporter exclusively interviewed the project of this project.。
Since the discovery of AIDS in the early 1980s of human beings，About 60 million people in the world have infected HIV。People talk about "Ai" color change，Scientists are also struggling to fight against AIDS。The fundamental，HIV genes change by 1 million times faster than the human body's normal gene，It has a layer of & quot; stake sports betting appstake online sports bettingsugar coat & quot;，The surface morphology of the virus changes in Wan Duan，All these，Makes human immune systems from being unable to send might，Scientists can only look at the ocean and sigh。
The team led by Dr. Gary Naber, the director of the Institute of Allergic and Infectious Diseases (NIAID) Vaccine Research Center of the National Health Research Institute (NIH)，First bind to a receptor molecule called CD4 on the human immune cell。Although HIV is extremely "cunning"，Good at changing，But the original sites used to bind to the CD4 receptor molecule are basically unchanged。This discovery is like finding the fatal weakness of AIDS- "Life Gate"。Garri Naber admits that after discovering the fate of HIV，It is even more difficult to find antibody cells for the "life door" site。
Garri Naber's most important challenges we encountered in the research process，is to design a protein that can make antibodies。And，It is also a very difficult process to convert the designed protein into a vaccine that can make antibodies。
Virus laboratory researcher in the blood sample of a 60 -year -old black gay man，It was detected that antibody cells that can produce "cover doors"，and through complex procedures，3 effective antibodies were found in the chance of only 8 millionth，Dr. Naber uses a sea to describe the way to find antibodies。
Garri Nabul: I regard this as a main focus of our paper。This method we use，To find very special cells。This time we found 3 of 25 million cells，As the saying goes, it is the sea to get a needle。
The project team further separated from these three antibodies to two more powerful AIDS antibodies My stake betting appstake betting appVRC01 and VRC02 from these three antibodies.。They can inhibit nearly 90%of the global popular HIV strains，Let people see the dawn of effective control of AIDS。
Garri Nabul: It is this discovery，Opened the door for further vaccine research。We believe，We will find 2-3 candidate vaccines in the next two or three years。They can open the channel for clinical trials。We will also use antibodies directly on the human body in clinical practice，This step is bypassing the vaccine，We can produce a large number of antibodies with the help of pharmaceutical companies。The antibody itself may also be used as vaccine and drugs。
Before 2008，Although many laboratories are separating AIDS antibodies，but I have not found effective、The antibody of the broad -spectrum，Even the famous laboratory claims "no existence of broad -spectrum antibodies"，This scientist who wants to use antibodies to develop AIDS vaccine，It is undoubtedly a blow in confidence。This discovery proves the first time in the human body that can naturally produce super -neutralized antibodies。
The significance of these two antibodies is also the meaning of，Give people a new idea for preventing and controlling other virus infection diseases。Taking flu as an example，This disease that everyone will be infected for life，The same amazing lethality。There are 250,000 to 500,000 per year because they suffer from influenza。The discovery process of the new AIDS antibody，For the treatment of influenza、Hepatitis B、Even cancer provides a new idea。
Gary Naber: We should be able to find hepatitis B virus faster、and even the weakness of cancer cells。But we will still My stake betting appStake Sports Bettingencounter the same challenge: we still have to figure out，Design and manufacture protein and vaccine，Go to the human body to produce antibodies。So say，This is an important research method、Research Tools。
Although the future is bright，Gali Naber also expressed caution。This discovery is like 500 miles from Chicago to New York，Just passing by a road sign，It is said to be 250 miles from New York，This means that you have gone through the long road，The direction is correct，But after all, there are 250 miles to go:
Garri Nabul: within two years，We will use these two methods，That is to say, the antibody itself or the antibody -based vaccine，Of course, it takes some time for vaccine development，After all, we have to do deeper tests，Not only to test the effect，Test safety、side effects。Most people think that it takes at least ten years，We can make the AIDS vaccine that appears for the world。
The latest two reports released by Science magazine，The first author of one of the articles is Zhou Tongqing，The first author of another article is Wu Xueling、Three people of Yang Zhiyong and Li Yuxing。Among the 24 -bit and 18th authors of the two signed，The names of Chinese scientists account for 8 and 10 bits, respectively，Among them, most people have completed university or even graduate education in mainland China，Scientists who study and work in the United States。Dr. Nabul praised these Chinese scientists in the entire project。
Garri Nabul: I think it is very lucky to have so many Chinese scientific elites to have so many Chinese scientific elites。Their text proves that they are very talented，stake sports betting appIt can be said that it stake sports betting appis the best and smarter scientist I have ever seen。Their talents can not only be reflected in the understanding of science，The vividly displayed in the process of scientific practice。We are very honored to have so many such capable scientists in our team。
In addition，The project team also cooperates with many Chinese research institutions，Especially China Disease Prevention and Control Center。When scientific research exceeds national borders，Fusion of each other，It will shine more brilliant light，This is science，This is the result of the joint efforts of scientists from all over the country。
The Voice of China Reporter exclusively interviewed the project of this project.。
Since the discovery of AIDS in the early 1980s of human beings，About 60 million people in the world have infected HIV。People talk about "Ai" color change，Scientists are also struggling to fight against AIDS。The fundamental，HIV genes change by 1 million times faster than the human body's normal gene，It has a layer of & quot; stake sports betting appstake online sports bettingsugar coat & quot;，The surface morphology of the virus changes in Wan Duan，All these，Makes human immune systems from being unable to send might，Scientists can only look at the ocean and sigh。
The team led by Dr. Gary Naber, the director of the Institute of Allergic and Infectious Diseases (NIAID) Vaccine Research Center of the National Health Research Institute (NIH)，First bind to a receptor molecule called CD4 on the human immune cell。Although HIV is extremely "cunning"，Good at changing，But the original sites used to bind to the CD4 receptor molecule are basically unchanged。This discovery is like finding the fatal weakness of AIDS- "Life Gate"。Garri Naber admits that after discovering the fate of HIV，It is even more difficult to find antibody cells for the "life door" site。
Garri Naber's most important challenges we encountered in the research process，is to design a protein that can make antibodies。And，It is also a very difficult process to convert the designed protein into a vaccine that can make antibodies。
Virus laboratory researcher in the blood sample of a 60 -year -old black gay man，It was detected that antibody cells that can produce "cover doors"，and through complex procedures，3 effective antibodies were found in the chance of only 8 millionth，Dr. Naber uses a sea to describe the way to find antibodies。
Garri Nabul: I regard this as a main focus of our paper。This method we use，To find very special cells。This time we found 3 of 25 million cells，As the saying goes, it is the sea to get a needle。
The project team further separated from these three antibodies to two more powerful AIDS antibodies My stake betting appstake betting appVRC01 and VRC02 from these three antibodies.。They can inhibit nearly 90%of the global popular HIV strains，Let people see the dawn of effective control of AIDS。
Garri Nabul: It is this discovery，Opened the door for further vaccine research。We believe，We will find 2-3 candidate vaccines in the next two or three years。They can open the channel for clinical trials。We will also use antibodies directly on the human body in clinical practice，This step is bypassing the vaccine，We can produce a large number of antibodies with the help of pharmaceutical companies。The antibody itself may also be used as vaccine and drugs。
Before 2008，Although many laboratories are separating AIDS antibodies，but I have not found effective、The antibody of the broad -spectrum，Even the famous laboratory claims "no existence of broad -spectrum antibodies"，This scientist who wants to use antibodies to develop AIDS vaccine，It is undoubtedly a blow in confidence。This discovery proves the first time in the human body that can naturally produce super -neutralized antibodies。
The significance of these two antibodies is also the meaning of，Give people a new idea for preventing and controlling other virus infection diseases。Taking flu as an example，This disease that everyone will be infected for life，The same amazing lethality。There are 250,000 to 500,000 per year because they suffer from influenza。The discovery process of the new AIDS antibody，For the treatment of influenza、Hepatitis B、Even cancer provides a new idea。
Gary Naber: We should be able to find hepatitis B virus faster、and even the weakness of cancer cells。But we will still My stake betting appStake Sports Bettingencounter the same challenge: we still have to figure out，Design and manufacture protein and vaccine，Go to the human body to produce antibodies。So say，This is an important research method、Research Tools。
Although the future is bright，Gali Naber also expressed caution。This discovery is like 500 miles from Chicago to New York，Just passing by a road sign，It is said to be 250 miles from New York，This means that you have gone through the long road，The direction is correct，But after all, there are 250 miles to go:
Garri Nabul: within two years，We will use these two methods，That is to say, the antibody itself or the antibody -based vaccine，Of course, it takes some time for vaccine development，After all, we have to do deeper tests，Not only to test the effect，Test safety、side effects。Most people think that it takes at least ten years，We can make the AIDS vaccine that appears for the world。
The latest two reports released by Science magazine，The first author of one of the articles is Zhou Tongqing，The first author of another article is Wu Xueling、Three people of Yang Zhiyong and Li Yuxing。Among the 24 -bit and 18th authors of the two signed，The names of Chinese scientists account for 8 and 10 bits, respectively，Among them, most people have completed university or even graduate education in mainland China，Scientists who study and work in the United States。Dr. Nabul praised these Chinese scientists in the entire project。
Garri Nabul: I think it is very lucky to have so many Chinese scientific elites to have so many Chinese scientific elites。Their text proves that they are very talented，stake sports betting appIt can be said that it stake sports betting appis the best and smarter scientist I have ever seen。Their talents can not only be reflected in the understanding of science，The vividly displayed in the process of scientific practice。We are very honored to have so many such capable scientists in our team。
In addition，The project team also cooperates with many Chinese research institutions，Especially China Disease Prevention and Control Center。When scientific research exceeds national borders，Fusion of each other，It will shine more brilliant light，This is science，This is the result of the joint efforts of scientists from all over the country。
