Exclusive variety、National Recall、Market disconnection、Patient panic & hellip; & hellip; recent，A drug for alleviating the symptoms of merit muscle weakness across the country。What is puzzling is，Obviously reserves a qualified product，But the interval is not distributed to the market for nearly one month; obviously has experienced several drug disconnection events，But still respond to weakness before the emergency。Cheap drugs break the incident frequently，Not only torture is the fragile market supply management mechanism of the enterprise，There are also precarious cheap drug living environment。

 

  See low -cost drugs! Early September，Follow Plug -of -Plasma D、Fish Subsidine Break the crisis，A required drug for patients with symptoms for patients with severe muscle weakness，The manufacturer recalls the country nationwide，The direct consequence is that patients in many places fall into panic without medicine。

 

  Compared with the frequent pharmaceutical supply incidents in recent years，The routine of the disconnection of the slices of bromidis is basically similar: first is the manufacturer's out stock，After the patient panic，Then put pressure on all parties，Finally resumed supply。Delivery the reason，Almost all the logic of the disconnection of cheap drugs is also nothing: manufacturers are less、Product price low、Small market size，Poor profitability。

 

  For companies that produce cheap medicines，The story of the broken supply of the medicine is not good。Normal supply，It may take the risk of continuous stake online sports bettingstake online sports bettinglosses; increase the price，It is likely to be criticized by patients as adulterers; but if the supply is stopped，Patients' hope of seeking medicine and seeking medicine for medicine is even more difficult to face。Also because of this，Each low -cost life -saving medicine or the disconnection of the must -have medicine，It will fall into the same difficulties: even if the government's administrative intervention，Make the supply of drugs temporarily recover，But if it does not solve the fundamental paradox of drugs and sexuality of cheap drugs，Broken supply will still be a sharp sword hanging on the patients of the patients。

 

  and this humble、Small cheap pills，For those who collapsed these diseases，Is a necessity for maintaining life and quality of life。

 

  1. What is going on?

 

  Back to the off -supply incident.

 

  For most people，& ldquo; Ming & rdquo; must be a strange eye，But for patients with severe muscles，These words can be regarded as part of life。Severe muscle weakness is a kind of acquisition of self -immune disease with a incidence of only 8.0 to 20.0/100,000 people，About 600,000 patients in the country，Its direct manifestation is the weakness of skeletal muscle contraction，Application of choline inhibitors can significantly reduce or relieve the symptoms。

 

  This time the confession & ldquo; the pine -bromozine movie & rdquo;。According to the 2015 version of China's severe muscle weakness diagnosis and treatment guide，Treatment of chiloholine inhibitors is an important way of severe treatment for severe muscle weakness，It is a first -line drug that treats all types of severe muscles，and can be used as a single medicine for long -term treatment of milder severe muscles。

 

  Xu Xianhao, a well -known neuromanological expert in our country, said，Bromorz is clearly a symptomatic drug，It can relieve the symptoms of severe muscle weakness，It is even more important to patients with weak respiratory muscles。Although there are still a lot of chilohne enzyme inhibitors at present，But from the clinical effect、In terms of adverse reactions and economic costs，Bromorz is the best choice。

 

  But，early September 2016，Discovery of many patients with weak muscle weakness，All ways to buy this drug were announced almost overnight。Whether it is the hospital、Pharmacy or online pharmacy，All the calibers are basically the same: currently the medicine has been out of stock，Re -supply time unknown。

 

  stake betting appstake sports betting appFor this，The explanation of Shanghai China and Western 3D Pharmaceuticals, the only domestic manufacturer of the drug: discovered during traceability and inspection of the available drugs，A total of 114 batches of bromidis produced from October 2015 to April 2016 have problems with abnormal drug dissolution，Therefore, the active report to the drug supervision department，and in accordance with the management measures of national drug recalls，I implemented the medicine & ldquo; III recall & rdquo;。

 

  According to the regulations of Chinese Pharmacopoeia，This medicine should be 80%dissolved in 60 minutes，But during the detection process of the manufacturer，The test results of 114 batches of drugs fluctuate around 80%，Most of them are between 70%-80%。Specifically，Abnormal dissolution means means that the disintegration time of the drug in the stomach is extended，Caused the dissolution time of the drug，It may affect the effectiveness of efficacy。

 

  It is understood，The scope involved in this recall includes about 4,000 hospitals nationwide、Pharmacy，And all unqualified batches will be destroyed under the supervision of the Shanghai Pharmaceutical Supervision Bureau。But，The recall event happened so quickly，so that many patients are not prepared in their families，Fatting into panic for a while。panic is only concentrated: What should I do next? Will this medicine discontinue production?

 

  2. Several occurrences of confession incidents

 

  The panic of the patient is not unreasonable。A must -have medication for patients with severe muscles，Pose of bromolecia currently has only three pharmaceutical manufacturers with production batch number，and only a company in Shanghai, a company in Shanghai, a company in Shanghai，What makes patients more panic is，This is not the first time to break the drug of bromoh。Feedback according to patients with severe muscle weakness，Since 2000 to the present，Pinerine's slices have been disconnected at least 4 times.，The reason for breaking the supply is a variety of: drug production line update、Factory relocation & hellip; & hellip;

 

  In the eyes of patients with severe muscle，At such a low price, manufacturers are willing to produce this medicine.。Packaging specifications of bromoz's slices are 60 tablets per box，and the price increase in recent years is not much。& ldquo; 2002 is 27 yuan，Now 35 yuan。& rdquo; Some patients said to E -drug managers。My stake betting appstake betting appBut the most worried，It is afraid that the company will stop production from here because of weak profits。

 

  Fortunately,，From the current point of view, this worry does not seem to happen。September 21，Shanghai Center Three -dimensional Pharmaceutical Industry through patient organizations & ldquo; Aili severe muscle weak care center & rdquo; vocalization expression，Called bromimis's pads will not stop production in the future，and have been under construction, a larger raw material production workshop and preparation workshop，It is expected to pass GMP certification in 2017。

 

  and the latest progress is，September 26，For five regions nearby (Jiangsu、Zhejiang、Shanghai、Guangdong、Anhui)，Enterprise has been shipped through logistics express，and other distant provinces and cities pass through air transport，It is expected to arrive in various provinces and municipal dealers before eleven，and send it to the hospital as soon as possible。Patients with bromois needed to buy this medicine at the local hospital after eleven。

 

  3, cheap drugs break the reflection

 

  This is the end，On the surface, things have been successfully ended。For patients，No matter what kind of torment after going through，But the medicine always resumes the supply，This is the most important thing。For enterprises，After all, the crisis of drug breaks has been processed again，It is given to the patient an explanation。

 

  To some extent，Due to the similar confession incident, it has appeared several times，Shanghai China West 3D Pharmaceuticals should have & ldquo; rich experience & rdquo;，but obviously it is，When the pharmaceutical confession is broken，The enterprise does not make enough preparations。

 

  First of all, it should be the company's market supply management mechanism。& ldquo; Product defects of abnormal dissolution & rdquo;，Let the pharmaceutical companies make a decision to make emergency recall nationwide，The recall decision made the patient group panic。

 

  After the market panic has appeared，Despite temporary mailing for some patients with urgent drug absence，But why not take larger measures in time，Relieve the emergency of market supply? In communication organized with patients，Introduction to the staff of the three -dimensional pharmaceutical industry in Shanghai，From June to September of each year, companies must discontinue production of production stake betting appstake betting appstake sports betting appequipment，But it will reserve enough medicines，To ensure market supply，At present, there are 8 batches of qualified medicines in the warehouse，But why is there a crisis in the market，It was not until September 26 that expert review would be held for quality release assessment?

 

  When answering & ldquo; Whether the drug break will occur in the future，Enterprise Representation，The new production workshop in 2017 is about to be put into use，By then, the drug production capacity will increase significantly。But the key to things is，The reasons for several times of stocking are not inadequate production capacity，More exposed is product quality control and market supply management issues，How will these problems be solved?

 

  But what I have to admit is，Under the precarious environment of cheap drugs，It is quite rare for companies to bear social responsibility for production。It is understood，Pinerine of bromoleis 2015 domestic market sales were only 9.9 million yuan，At the same time, bromoz's slices also belong to a variety that must be completed by the consistency evaluation of generic drugs by the end of 2018，Adhering to this medicine is undoubtedly a great pressure for the manufacturer。