Among the existing 3,500 medicines，Only more than 60 kinds of children used for children，accounting for 1.7%of the total

 

  At least 50%of drugs do not marked children's usage when used in pediatrics、Dosage

 

  That kind of child is & ldquo; Little adults & rdquo;，Pediatric medication is half -、The point of reduction is wrong

 

  About 30,000 children in my country are caught in a silent world due to improper medication。The incidence of adverse reactions of children's drugs is 12.5%，Two times the adult，Newborn as high as 24.4%，4 times the adult

 

  Due to pediatric & ldquo; lack of medicine & rdquo;，The number of children 5 to 14 every year in my country may be as many as 100,000 people who can prevent and treat diseases.

 

  The research and development obstacles of children's medicine are mainly clinical trials and R & D investment，Urgently need policy assistance

 

  5 -year -old Fu Yinuo 3 years ago caused deafness due to improper medication，The whole family of the right family looks like a thunderbolt。& ldquo; I feel that there is no hope in life。& rdquo; Mother 浠 Nuo told the news weekly magazine。

 

  Mother of 浠 Nuo said，The whole family almost traveled to major hospitals for this，I dare not neglect a hint of hope，But the doctor’s conclusion is，Neurological deafness cannot be cured at present，Can only rely on auxiliary hearing aids，If you can't, you can implant a cochlear。

 

  This pain of cutting skin，Make Momo Mom realizes: in terms of medication，Children are not adults & ldquo; Reduced version & rdquo;，Children should use children's medicine，Mistration medication may affect the child's life。

 

  浠 Nuo is not a lonely example。According to statistics from the China Deaf Children Rehabilitation Research Center，About 30,000 children in my country are caught in a silent world due to improper medication。According to statistics，The incidence of adverse reactions in children in our country is 12.5%，Two times the adult，Newborn as high as 24.4%，4 times the adult。

 

  Yao Hongwen, the director of the China Population Education Center, Yao Hongwen, & ldquo;。He commented to the News Weekly of "Looking": & ldquo; Behind these numbers，Not only children who are hurt，It also brings a lot of misfortune to the child's family，Bring a heavy burden to the society。& rdquo;

 

  Behind the severe situation of adverse reactions of children's drugs，It is the reality of Chinese children & ldquo; lack of medicine & rdquo;。"2016 Children's Drug Safety Survey Report White Paper" (hereinafter referred to as "White Paper") shows: At present, the number of children in my country accounted for 19.3%of the patients.，Among the existing 3,500 medicines，Only more than 60 kinds of children are used for Stake Sports Bettingchildren，stake sports betting appOnly 1.7%of the total。

 

  As of 2014，About 230 million children in my country，accounting for about 16.5%of the total population。How to change the reality of Chinese children & ldquo; lack of medicine & rdquo;，Ensure the basic medication needs of children? What are the obstacles to the company's customized & rdquo; what are the problems?，Urgently need to break through。

 

  The sufferings of the shortage of children's medication

 

  From more than 20 years ago, I went to work in Beijing Children's Hospital，Wang Xiaoling noticed a scene: Every day the pharmacist must crush the tablets into powder and then dose。& ldquo; For more than 20 years，The pharmacists of our hospital have changed several times，But this scene has not changed。& rdquo;

 

  Wang Xiaoling is the director of the pharmaceutical department of Beijing Children's Hospital。In her opinion，Tablet doses into powder and then dose，It means that children's drugs are in dosage form、Insufficient specifications。

 

  Wang Xiaoling was commissioned by the State Health and Family Planning Commission to conduct a survey。The results show，In the pediatrics of 15 large children's hospitals across the country，The dosage form is in front of the injection、tablets，There are only 21 oral solution agents。& ldquo; This is for young children，It means that they may face the situation where there is only tablets to choose from，This requires dividing the tablets into 1/2 tablets、1/4 tablets，For newborns，It may get 1/8 or even smaller，Once the division is uneven，It may cause drug damage。In addition，Syphroditizer and other dosage types suitable for children are also very limited。& rdquo;

 

  In dosage、In addition to specifications，The shortage in the number of children's medicines cannot be ignored。The survey of Wang Xiaoling's Wang Xiaoling shows，There are 1098 species of pediatric directory of 15 large pediatric hospitals in the country，There are only 45 species for children's special medicines，accounting for 4%，Among the remaining 1053 drugs，Children's usage、About 43%of the variety of dosage。& ldquo; This means，At least 50%of drugs do not marked children's usage when used in pediatrics、Dosage。Children's medication manual and shortage of medication information，and the usage of children's medication、The dosage is not clear，It also makes pediatricians face the dilemma of law and clinical difficulties every day，If you are not careful, you may lead to medication for the superior manual。& rdquo; Wang Xiaoling said。

 

  Another disclosure of "White Paper"，As of June 2016，my country's Food and Drug Administration has a total of 176652 of domestic drugs，Among them, the drug approved for children is 3517，accounting for 2%of the total number of drugs for drugs。Where，Chinese patent medicine accounts for 68.5%，Chemical drugs account for 31.5%。From the perspective of drug treatment，Mainly concentrated in the respiratory system、Gastrointestinal System，There are fewer indications in other fields。& ldquo; This shows that the treatment field of existing children's drugs is narrow。& rdquo; General Manager Zhang Stewen said。

 

  Academician of the Chinese Academy of Engineering、Traditional Chinese Medicine Pharmaceutical Expert Li Lianda told the News Weekly，At present, there is a misunderstanding，Think that children are & ldquo; Little adults & rdquo;，Pediatric medication is half -、Reduce，This is wrong。Because children have their own growth and development rules stake online sports bettingStake Sports Bettingand physiological pathological characteristics，Children's disease occurred、Development and transfer is particularly special。& ldquo; Even if children and adults have the same disease，Its development rules are not the same，Selected prescription medication、Note、The rules of medication are also different。& rdquo;

 

  Wang Xiaoling said，Due to pediatric & ldquo; lack of medicine & rdquo;，Children aged 5-14 each year，The number of people who died in preventing and treating diseases may be as many as 100,000。& ldquo; 125 children around the world die for poisoning every day，Poisoning is also a child damage in my country、The main cause of death。& rdquo;

 

  "2015 Children's Drug Safety Report" shows，In the children's group，Drug poisoning accounts for the proportion of all poisoning children，From 53%in 2012 to 73%in 2014。Look from this data，& ldquo; It is serious to hurt children。& rdquo; Wang Xiaoling said。

 

  The reasons for children's drug poisoning are mostly mistakenly taken。This means，Pharmaceutical Manual is important for pediatric drug safety。Wang Xiaoling said，At present, the drug manual in my country is still confused，Children's medicinal dynamics data is seriously insufficient。& ldquo; We hope that the state can ask the enterprise to hang the latest drug manuals on the official website，Even the database of a drug instruction manual like a developed country，and a comprehensive evaluation system for clinical medication for children and an active monitoring system for adverse reactions to children，Establishing a child's pharmacy database database，Let children take more medicine、More reliable scientific information and basis。& rdquo;

 

  Difficulties in the development of children's medicine

 

  Focusing on children's medicine since 2007，Sunflower Pharmaceutical has been working in the child's medicine market for nearly 10 years。Chairman Guan Yanbin told "Looking" News Weekly: & ldquo; Chunjiang Water Warm Duck Prophet，We have long been aware of the problems of children & lsquo;。& rdquo;

 

  According to Guan Yanbin，Sunflower Pharmaceutical Group has 69 children's medicines，The retail sales of children's medicines listed in 2015 exceeded 5 billion yuan，It has become a banner of current domestic children's medicine manufacturers。

 

  Despite this，Sunflower Pharmaceutical still deeply feels deeply feeling for children & ldquo; tailor -made & rdquo;。

 

  Guan Yanbin said，The research and development obstacles of children's medicine are mainly clinical trials and R & D investment。From the clinical trial，Almost no mother is willing to let her children bear the risk of clinical trials，This is a problem faced by the world。Investment from research and development，Although children's medication and adult medication are also large investment、cycle long、Big risk，But usually，The profit of children's medicine is far lower than adult medicine，For example，The annual sales of an adult medicine may reach billions of sales after the successful development of adult medicine、tens of billions，But the annual sales of children's medicines are usually only one or two billion，At least two or three billion，So，The enthusiasm for developing children's medicine for enterprises is not high，There are also few manufacturers of children's medicines。

 

  A survey by the National Federation of Industry and Commerce Pharmaceutical Chamber of Commerce，Among more than 6,000 pharmaceutical factories nationwide，Only Stake Sports Bettingmore than 10 people specializing stake sports betting appin children's medication，Among them, Beijing Shou'er Pharmaceutical Factory、Tianjin Children's Pharmaceutical Factory、Harbin Children's Pharmaceutical Factory Co., Ltd.。In addition，There are only more than 30 companies with children's drug production departments，Ruwu Pharmaceutical Group、Guangzhou Baiyunshan Pharmaceutical Co., Ltd.、North China Pharmaceutical Co., Ltd., etc.，But more than 90%of the children's medication medical market is occupied by a small number of foreign companies。

 

  From the market size of children's medicine，The market size of children's medicines in my country has increased from 38.35 billion yuan in 2011 to 52.66 billion yuan in 2014，Compound growth rate reaches 11.2%，But in terms of more than 10 trillion pharmaceutical markets，Only about 4%。

 

  Urgently need policy assistance

 

  The development of children's medicine obviously requires more policy support.

 

  Back to the relevant policies and regulations of Chinese children's medication since 2003，"Several Opinions on Ensuring Children's Medicine" (hereinafter referred to as "Opinions") introduced in 2014 can be called the first comprehensive guidance document in China。Opinions by the National Health and Family Planning Commission、The National Development Reform Commission and other six ministries and commissions jointly issued，Encourage R & D Innovation、Accelerate the application for approval、Make sure production supply、Strengthen quality supervision、Promoting reasonable medication and other links all propose specific requirements。

 

  "Opinions" after landing，The change of the bidding policy follows the following。February 2015，The General Office of the State Council issued the "Guiding Opinions on Improved Public Hospital's Centralized Procurement Work"，Put forward & ldquo;、Urgent (grab) rescue medicine、Basic infusion、Drugs with small clinical dosage (the specific scope of the above drugs is determined by provinces, autonomous regions and municipalities) and commonly used low -cost drugs，Implementation of centralized hanging network，directly purchased from the hospital & rdquo;。

 

  January 2016，Adjustment policy adjustment。The review and approval center of the State Food and Drug Administration issued the "Basic Principles of the Evaluation of Priority Review Approval for Children's Drug for Children's Drugs"，It is proposed that the application for drug registration for children's diseases and obvious clinical advantages can speed up review and approval。

 

  June this year，The General Office of the National Health and Family Planning Commission, etc., jointly issued the "First Batch of Encouraging R & D and Application for Children's Drugs" to be clear，The medicine included in the list，Its R & D declaration is encouraged by policy。

 

  Facing the continuous good policy，Guan Yanbin said that his expectations are very simple: & ldquo; Our enterprise just hopes that these good policies can really be implemented。In recent years, the country has successively introduced a series of & lsquo; Huier & rsquo; policy，But there are still some problems in the policy implementation link。From the corporate level，The industrial promotion brought by national policy has not yet been implemented，It also needs active action from all walks of society，Working together to advance steadily。& rdquo;

 

  Specific to approval stake betting apppolicy，Guan Yanbin for example，Some traditional stake sports betting appChinese medicine is very classic for traditional Chinese medicine，It is also very easy to use，But they often have a big problem，It's not delicious，Children are unwilling to eat。At the same time, their administration is not convenient，Mainly scattered agent，You need to take water and open it，Chinese medicine children are not very acceptable，So parents often pinch their children's nose and pour it into the mouth。For this traditional Chinese medicine，If we change its dosage formation through modern science and technology、Taste，For example, if they become frozen -like、Drug -like medicine，Make their flavors into strawberry flavor、Orange flavor，Children's acceptance will increase，It will be more convenient to take it。But from the current point of view，This improved dosage form type under the premise of ensuring quality、Change the taste，Although the approval policy has been recognized in the approval policy，But in some places, I haven't really implemented it yet。

 

  Fang Shuting, president of China Chinese Medicine Association, pointed out，Children's medication is developing、Transfer、Production、Use、Sales and other links still need more policy support，Need the government to give more attention to enterprises，Make companies be more active for children & ldquo; tailor -made & rdquo; drugs。

 

  Wang Xiaoling said，There are fewer manufacturers of children's medicines in my country，Specifications for children's medicine、There are relatively few dosage forms，As a result, many children with diseases can be available，or adult medicine for children for children，Added the risk of child medication safety。& ldquo; We look forward to more policy encouragement，Children can have more exclusive drugs available、Optional，Also allows our doctors to no longer have no & lsquo; weapon & rsquo;、Lack of & lsquo; weapon & rsquo; worry。& rdquo;