3 months ago，China has been listed on the world's first hand, foot, and mouth -and -mouth active vaccine。3 months later，Most people are still difficult to find local vaccines。

 

  January to April this year，Domestic hand, foot and mouth epidemic even increased by 27%over the same period last year。Behind the weird phenomenon，It is the second -class vaccine new policy.，After adjustment of the interests of the local illness and control department，How to effectively maintain the problem of the second vaccine vaccination system。

 

  China Disease Prevention and Control Center (hereinafter referred to as China Disease Control) public data display，January to April 2016，The cumulative number of hand -foot and mouth cases in the Mainland of my country exceeds 400,000 cases，increased by 27%compared to the same period in 2015。Where，The provincial and districts with a large number of cases of reports are Guangxi、Guangdong、Hunan、Anhui and Zhejiang，More than half of the total number of infectious cases of hand, foot, and mouth。

 

  This kind of infectious diseases that are generally susceptible to infants under the age of three，Each year continues to explode during a fixed period。Although most patients have mild symptoms，But myocarditis may appear in severe children、pulmonary edema、Encephalitis，and can cause death。Among them, cases caused by EV71 infection are particularly serious，can lead to 80%severe cases、93%of death cases。

 

  Display data display，Only March to April this year，Children who die due to hand -foot and mouth disease have reached 22 people。In Guangxi、Sichuan，Some severe children died due to severe damage due to the nervous system。In Guangxi，Two -year -old children have only five days from their onset to death;，A 1 and a half -year -old left -behind child，Because the only old man in the family is not discovered in time，Died on the way to the doctor。

 

  They could have avoided death in non -life。March 2016，China's EV71 activation vaccine has been officially approved for listing。As the only EV71 activated vaccine product produced by human -based cell matrix，It fills the global market gap。Where，Kunming Institute (hereinafter referred to as Kunming Institute) stake sports betting stake sports betting appappof the Institute of Medicine and Biology of the Chinese Academy of Medical Sciences and Beijing Kexing Biological Company, both of which are separated from key virus strains，Developed vaccine and went public in succession。

 

   & ldquo; We will definitely play for the vaccine，But how can there be a vaccine? & rdquo; Zhao Qin sees the message of hand, foot and mouth vaccine on the media，Go to ask the doctor，But I ate closed doors。

 

   & ldquo; No vaccine。& rdquo; This is the answer from most vaccine doctors across the country。Although it has been listed for more than three months，The number of infected people continues to increase，The anxious parents still have no seedlings。

 

  One seedlings are difficult to sell

 

   & ldquo; All work has stagnated。Not only us，All companies that produce second -class vaccines are almost retail last month。& rdquo;。

 

   & ldquo; We encountered unprecedented difficulties。& rdquo; Yin Weidong watched the 900,000 EV71 vaccine lying in the cold storage.。As the general manager of Kexing Biological Company，EV71 vaccine is the biggest harvest for their eight years of research and development，Seeing that you can return to generosity after the listing in May，But more than a month passed，The vaccine is not sold out。

 

  The situation of Kunming, which was launched in March, was slightly better。But only after sending a small part of it，Their millions of EV71 vaccines are also stranded in the warehouse。

 

  This is hard to imagine。As early as March 18，"Yunnan Daily" published news previews，& ldquo; Starting March 22, children across the country can perform EV71 vaccination。& rdquo;

 

  April to July every year is the peak period of the outbreak of hand, foot and mouth disease。& ldquo; We rushed to go public before April，It is to prevent children from being able to prevent children before this year's popular season。& rdquo; An expert who participated in the research and development of Kunming said。

 

  This is related to the regulations that change the vaccine industry。March 2016，Shandong vaccine case sensation nationwide，Vaccine operating enterprises collude with the personnel of the disease control system.。April 13, 2016，Executive Meeting of the State Council decided to revise the "Regulations on the Management of Vaccination and Prevention"，Make major adjustments to the supply channel of the second type of vaccine (that is, the self -funded vaccine)。

 

  To reduce intermediate links，Stop the borrowing qualifications and bills for illegal operations & ldquo;，The revised regulations stipulate that the second type of vaccine that is voluntarily vaccinated is compared with the first type of vaccine used in the national immunization plan，All included in the provincial public resource trading platform for centralized procurement，No longer allows drug wholesale enterprises to operate vaccines。Vaccine manufacturers directly and distribute second -class vaccines to county -level disease control，or entrusted to have a cold chain storage、Enterprise delivery of transportation conditions，No longer passes through the original delivery channel of the provincial and municipal level。

 

  Simply speaking，The state hopes to cut off everything that may be greasy，Let stake betting appthe enterprise supply stake betting appdirectly to the grassroots district and county。

 

  The self -funded vaccine market has changed the drama。Most companies rely on agents，In the future, you can only rely on the self -built sales team of the enterprise。Many drug wholesale enterprises operate with vaccine as the main business，Previously, I had to obtain vaccine business qualifications，Software and hardware investment huge，Standing qualifications to terminate their vaccine operations are almost equal to letting them close。and because the corresponding execution rules and bidding platforms have not been introduced in various provinces。More than two months passed，Most of the nation's regions cannot be purchased by self -funded vaccines，It can only consume inventory。

 

   & ldquo; It should be able to hold it in a short time，But it won't be long after it can be supported。& rdquo; The person in charge of a medical control department in Beijing said。The situation in other places is worse，Nanjing、Nanning、Shenzhen and other places directly hung out of the shortage notification。

 

  Although it affects or is short -term，But when the regulations are just come out，No one realizes that it will have such a great impact on the entire vaccination in vaccination。

 

  June 14，The State Food and Drug Administration and the State Health and Family Planning Commission of the two ministries and commissions issued by the new regulations，A promised places have eight months of transition period，The old measures and the adoption of the new regulations during the transition period are permitted。

 

   & ldquo; May also see a problem，Try to correct bias。& rdquo; But this has little effect on solving the current problem，& ldquo; Everyone knows，After the implementation of the new regulations，Provincial and municipal disease control does not participate in second -class vaccination，Who will still use the old method more now? & rdquo; Deputy Director of a Provincial Centers for Disease Control and Prevention。

 

  Difficulty of During the Division

 

  In the past week，Southern Weekend reporters contacted Beijing respectively、Shanghai、Guangdong、Sichuan、Yunnan、Guangxi、Shandong、Hunan、Multi -level disease control systems in Anhui and other places，Most of them are silent。

 

  But roughly count the construction of the second -class vaccine bidding platform across the country，It can be found that although many provinces have issued documents in the near future，Further tighten the management of second -class vaccination，Announced the purchase of vaccine announcement online，But most of them are still soliciting opinions，There are still some provinces who have not introduced policies。Only Sichuan is really built and used、Zhejiang and other very few areas。& ldquo; When will you recover，No timetable。& rdquo; Li Ning said。

 

  In fact，The establishment of the second type of vaccine platform is very simple，It can be made in a week。Liu Yongchao, a service provider of the vaccine industry, told the southern weekend reporter，The bidding platform of vaccine and medicine is not the same，The bidding of the first type of vaccine stake online sports bettingin each province is also perfect。

 

  My stake betting appPromotion is slow because of the consideration of benefits。& ldquo; The Shandong vaccine case covered the entire disease control system。& rdquo; From Li Ning's view，Because they are questioned by the public、Rejects、Abuse，Now everyone would rather not do it，I don’t want to be misunderstood。Once actively promotes the platform of second -class vaccines，Instead, I was accused of making money to make money。This psychology exists in many provinces。

 

  This is also related to the assessment system of vaccination。In China，The government has the requirements for the assessment of free vaccination rate for free vaccine，At the same time, there are vaccination subsidies。while the self -funded vaccine has no vaccination rate，No vaccination subsidy。Whether free or self -funded vaccine，There are vaccine science science education and adverse reactions to be dealt with，This often consumes a lot of manpower。& ldquo;，No one wants to do it。& rdquo; A grass -roots vaccination person said。

 

   & ldquo;、Two categories are not classified by important degree，Need to properly guide the people's understanding。& rdquo; Dong Xiaoping, deputy director of the Virus Directors of the China Disease Prevention and Control Center said，It is difficult for governments in the world to cover all vaccines，But the blocking of vaccines for disease epidemic is a good guarantee。Although the second -class vaccine is the company's sales，But governments at all levels are required，Explain the advantages and disadvantages with the people，Let them choose themselves，& ldquo; This cannot be said by the enterprise。& rdquo;

 

  In some provinces with severe epidemics，Diseases and control staff are very anxious。Two weeks ago，Zhu Xiaoping, deputy director of the Sichuan Provincial Disease Prevention and Control Center, said at an internal meeting，I hope to use the EV71 vaccine as soon as possible，Easy children with more than 6 months，The earlier, the better the better。As a province with a serious epidemic，Chengdu this year's new legal infectious cases，Half of them are hand, foot and mouth disease。

 

  At present, there are 374 county -level cities in the country，1636 counties，852 municipal jurisdiction，Total 2863 county -level disease control centers。How to face the huge grassroots，Enterprises are also very difficult to deliver vaccines。R & D personnel of a vaccine company are frank，If you all have to bear the company，Vaccine in remote areas, they are unwilling、Can't get it。

 

  Cold chain delivery cost is determined by volume (the corresponding is actually a single vaccine) and the number of single delivery。For a certain destination and the quantity，The cost of each vaccine is almost，Basically have nothing to do with the value of vaccine。This will lead to low -cost vaccine's delivery fees accounted for a high high，Selection of market laws，In the end, it may lead to a vaccine that is very important for the prevention and control of the epidemic.，Disappearing or difficult to vaccinate。

 

  Policies have soared?

 

  I want to break the centers and control channel monopoly、Stake Sports BettingReduced the price of self stake sports betting app-funded vaccine through market competition。But no one expected，After the regulations are revised，Enterprises need new cold chain system and logistics，Add bidding purchase link，but increased the cost of the vaccine。Multiple industry people forecast，If the government does not make corresponding subsidies，Class 2 vaccine will increase the price significantly。

 

  Government pharmaceutical procurement system information display，EV71 vaccine produced by Beijing Kexing Biological Products Co., Ltd.，divided into two types: Xilin bottle and pre -charging injection，The highest price limit is 168 yuan and 188 yuan。EV71 vaccine produced by the Institute of Medicine and Biology, Chinese Academy of Medical Sciences，Divided into Xilin bottle and pre -irrigated blocks，The highest price limit is the same as before。

 

  March 28 this year，Nearly 50 children in Kunming have become the first vaccine (produced by the Chinese Academy of Sciences)，Vaccine is recommended to retail price 218 yuan/time。Depending on，EV71 The vaccination target of an active vaccine is June to 5 -year -old children，Basic immune program is 2 doses，1 month interval。That is to say，EV71 This type of second -class vaccine needs to pay more than 400 yuan at their own expense。

 

  But with the introduction of the New Deal，The price becomes elusive。& ldquo; Now the operation costs such as transit in the new mode of budgets are unable to budget，Therefore, the price of the second -class vaccine has been greatly increased。Sichuan disease control people say that the second -class vaccine price is doubled than the previous model。& rdquo; Li Ning said。

 

  Dong Xiaoping worry: Once the cost of transportation is added，Prices in various places will inevitably be different。Will it become，Economic and developed big cities such as Beijing, Shanghai, Guangzhou，Class 2 vaccine prices are cheap，In remote western provinces，Prices will soar? (This article is deleted)